| Identification | Back Directory | [Name]
HDAC3 Inhibitor | [CAS]
2044701-99-5 | [Synonyms]
HDAC3 Inhibitor
HDAC-3 Inhibitor,HDAC3 Inhibitor
Benzoic acid, 4-[[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]amino]methyl]-, 2-propylhydrazide | [Molecular Formula]
C20H23N3O2 | [MOL File]
2044701-99-5.mol | [Molecular Weight]
337.42 |
| Chemical Properties | Back Directory | [Boiling point ]
562.5±50.0 °C(Predicted) | [density ]
1.140±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml | [pka]
12.55±0.23(Predicted) |
| Hazard Information | Back Directory | [Uses]
HDAC3-IN-1 (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM[1]. | [IC 50]
HDAC3: 5.96 ± 0.0 nM (IC50); HDAC1: 36.4 ± 0.2 nM (IC50); HDAC2: 89.9 ± 0.7 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Moreno-Yruela C, Olsen CA. Determination of Slow-Binding HDAC Inhibitor Potency and Subclass Selectivity. ACS Med Chem Lett. 2022 Mar 16;13(5):779-785. DOI:10.1021/acsmedchemlett.1c00702 |
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