| Identification | Back Directory | [Name]
2614W94 | [CAS]
205187-35-5 | [Synonyms]
2614W94
Phenoxathiin, 3-(2,2,2-trifluoro-1-methylethoxy)-, 10,10-dioxide | [Molecular Formula]
C15H11F3O4S | [MDL Number]
MFCD31382159 | [MOL File]
205187-35-5.mol | [Molecular Weight]
344.31 |
| Chemical Properties | Back Directory | [Boiling point ]
440.8±45.0 °C(Predicted) | [density ]
1.449±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
2614W94 is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and IC50 of 5 nM and Ki of 1.6 nM with serotonin as substrate. | [in vivo]
2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED50 of 1.1 mg/kg[1]. | [References]
[1] Helen L. White, et al. Biochemical and Pharmacologic Properties of 2614W94, a Reversible, Competitive Inhibitor of MonoamineOxidase-A. DRUG DEVELOPMENT RESEARCH 45:1-9 (1998). |
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MedChemExpress
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