| Identification | Back Directory | [Name]
CX-157 | [CAS]
205187-53-7 | [Synonyms]
CX-157
Phenoxathiin, 3-fluoro-7-(2,2,2-trifluoroethoxy)-, 10,10-dioxide | [Molecular Formula]
C14H8F4O4S | [MDL Number]
MFCD18633273 | [MOL File]
205187-53-7.mol | [Molecular Weight]
348.27 |
| Chemical Properties | Back Directory | [Boiling point ]
430.0±45.0 °C(Predicted) | [density ]
1.549±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO |
| Hazard Information | Back Directory | [Uses]
CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL. | [in vivo]
CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL. CX-157 is an investigational compound currently in development for the treatment of major depressive disorder (MDD). Mechanistic studies in animals have shown that CX-157 acts to inhibit MAO-A activity in a reversible and competitive manner, elevating brain levels of monoamine neurotransmitters[1]. | [References]
[1] Fowler JS, et al. Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31. DOI:10.1038/npp.2009.167 |
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| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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