| Identification | Back Directory | [Name]
Tubulysin B | [CAS]
205304-87-6 | [Synonyms]
Tubulysin B
Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)- | [Molecular Formula]
C42H63N5O10S | [MDL Number]
MFCD29477701 | [MOL File]
205304-87-6.mol | [Molecular Weight]
830.04 |
| Chemical Properties | Back Directory | [Boiling point ]
978.0±65.0 °C(Predicted) | [density ]
1.204±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
4.52±0.23(Predicted) | [color ]
White to off-white | [InChIKey]
HWCIETDQUHYHGQ-OSGLCLOFNA-N |
| Hazard Information | Back Directory | [Description]
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agent isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug-resistant properties. It is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.
| [Uses]
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2]. | [Definition]
ChEBI: Tubulysin B is a butyrate ester. | [in vitro]
Tubulysin B has IC50s of 0.6 and 0.9 nM against KB and A549 tumors cell lines, respectively.
| [References]
[1] Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813. DOI:10.1021/acs.bioconjchem.9b00335
[2] Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. DOI:10.1016/j.bmcl.2011.09.041 |
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NewCan Biotech Limited
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+86-0571-86912261 +86-15658003402 |
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https://www.newcanbio.com/ |
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