| Identification | Back Directory | [Name]
Methanone, [2-[(3-pyridinylmethyl)amino]-5-pyrimidinyl]-2-thienyl- | [CAS]
2054952-13-3 | [Synonyms]
Vanin-1-IN-2
Methanone, [2-[(3-pyridinylmethyl)amino]-5-pyrimidinyl]-2-thienyl- | [Molecular Formula]
C15H12N4OS | [MOL File]
2054952-13-3.mol | [Molecular Weight]
296.35 |
| Hazard Information | Back Directory | [Uses]
Vanin-1-IN-2 is a potent vanin-1 inhibitor with an IC50 of 162 nM. Vanin-1 is a cell-surface-associated, glycosylphosphatidyl inositol (GPI)-anchored protein which is expressed at high levels in the kidney, liver, and small intestine[1]. | [References]
[1] Casimiro-Garcia A, et al. Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem. 2022;65(1):757-784. DOI:10.1021/acs.jmedchem.1c01849 |
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