| Identification | Back Directory | [Name]
N-(Mal-PEG6)-N-bis(PEG3-amine) TFA salt | [CAS]
2055040-99-6 | [Synonyms]
N-(Mal-PEG6)-N-bis(PEG3-amine)
N-(Mal-PEG6)-N-bis(PEG3-amine) TFA salt | [Molecular Formula]
C38H71N5O16 | [MDL Number]
MFCD31814451 | [MOL File]
2055040-99-6.mol | [Molecular Weight]
853.99 |
| Chemical Properties | Back Directory | [Boiling point ]
898.7±65.0 °C(Predicted) | [density ]
1.176±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF | [pka]
15.01±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(Mal-PEG6)-N-bis(PEG3-amine) is a water soluble PEG linker containing a maleimide and two amino groups. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. | [Uses]
N-(Mal-PEG6)-N-bis(PEG3-amine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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