| Identification | Back Directory | [Name]
m-PEG3-Sulfone-PEG3-t-butyl ester | [CAS]
2055041-00-2 | [Synonyms]
m-PEG3-Sulfone-PEG3-Boc
m-PEG3-Sulfone-PEG3-t-butyl ester
4,7,10,16,19,22-Hexaoxa-13-thiatricosanoic acid, 1,1-dimethylethyl ester, 13,13-dioxide | [Molecular Formula]
C20H40O10S | [MDL Number]
MFCD29918256 | [MOL File]
2055041-00-2.mol | [Molecular Weight]
472.59 |
| Hazard Information | Back Directory | [Description]
m-PEG3-Sulfone-PEG3-t-butyl ester is a PEG linker containing sulfone and t-butyl ester moieties. The sulfone can react with thiol groups of proteins. The t-butyl can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | [Uses]
m-PEG3-Sulfone-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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