| Identification | Back Directory | [Name]
Mal-PEG8-t-butyl ester | [CAS]
2055048-43-4 | [Synonyms]
Mal-PEG8-Boc
Mal-PEG8-COOtBu
Mal-PEG8-CH2CH2COOtBu
Mal-PEG8-t-butyl ester
4,7,10,13,16,19,22,25-Octaoxaheptacosanoic acid, 27-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C27H47NO12 | [MDL Number]
MFCD30458029 | [MOL File]
2055048-43-4.mol | [Molecular Weight]
577.66 |
| Chemical Properties | Back Directory | [Boiling point ]
625.7±55.0 °C(Predicted) | [density ]
1.144±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [form ]
Oil | [pka]
-2.34±0.20(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Mal-PEG8-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Uses]
Mal-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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