| Identification | Back Directory | [Name]
(R)-KT109 | [CAS]
2055172-60-4 | [Synonyms]
(R)-KT109
(R)KT109,(R)-KT-109,(R) KT109
Methanone, (4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[(2R)-2-(phenylmethyl)-1-piperidinyl]- | [Molecular Formula]
C27H26N4O | [MOL File]
2055172-60-4.mol | [Molecular Weight]
422.52 |
| Chemical Properties | Back Directory | [Boiling point ]
637.3±53.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml | [form ]
A crystalline solid | [pka]
-1.02±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
(R)-KT109 is a highly potent inhibitor of diacylglycerol lipase β (DAGLβ) with an IC50 of 0.79 nM and effectively blocks DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol. Additionally, it demonstrates inhibitory activity against α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 of 2.51 nM, exhibiting greater potency for DAGLβ, DAGLα, and ABHD6 compared to its (S) isomer, (S)-KT109. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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