| Identification | Back Directory | [Name]
Aminooxy-PEG8-acid | [CAS]
2055269-60-6 | [Synonyms]
Propanoic acid, 3-[[23-(aminooxy)-3,6,9,12,15,18,21-heptaoxatricos-1-yl]oxy]- | [Molecular Formula]
C19H39NO11 | [MDL Number]
MFCD28015777 | [MOL File]
2055269-60-6.mol | [Molecular Weight]
457.51 |
| Hazard Information | Back Directory | [Uses]
Aminooxy-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Aminooxy-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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