| Identification | Back Directory | [Name]
3-Thiazolidinepropanoic acid, 5-[[5-(4-chlorophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-, (5Z)- | [CAS]
2055732-24-4 | [Synonyms]
Claficapavir
3-Thiazolidinepropanoic acid, 5-[[5-(4-chlorophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-, (5Z)- | [Molecular Formula]
C17H12ClNO4S2 | [MOL File]
2055732-24-4.mol | [Molecular Weight]
393.86 |
| Chemical Properties | Back Directory | [Boiling point ]
594.9±60.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 200 mg/mL (507.79 mM; ultrasonic and warming and heat to 40°C) | [form ]
Solid | [pka]
4.30±0.10(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1[1]. | [IC 50]
HIV-1 | [storage]
Store at -20°C | [References]
[1] Kim MJ, et al. Identification and characterization of a new type of inhibitor against the human immunodeficiency virus type-1 nucleocapsid protein. Retrovirology. 2015;12:90. Published 2015 Nov 6. DOI:10.1186/s12977-015-0218-9 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|