| Identification | Back Directory | [Name]
PC Methyltetrazine-PEG4-NHS carbonate ester | [CAS]
2055736-28-0 | [Synonyms]
PC Methyltetrazine-PEG4-NHS carbonate ester
Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-4-[[16-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]-4-oxo-8,11,14-trioxa-5-azahexadec-1-yl]oxy]-2-nitrophenyl]ethyl ester | [Molecular Formula]
C35H43N7O14 | [MDL Number]
MFCD29052192 | [MOL File]
2055736-28-0.mol | [Molecular Weight]
785.75 |
| Hazard Information | Back Directory | [Uses]
PC Methyltetrazine-PEG4-NHS carbonate ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PC Methyltetrazine-PEG4-NHS carbonate ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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