| Identification | Back Directory | [Name]
MC-Val-Cit-PAB-tubulysin5a | [CAS]
2055896-86-9 | [Synonyms]
MC-VC(S)-PABQ-Tubulysin M
Mc-Val-Cit-PAB-Tubulysin M
MC-Val-Cit-PAB-tubulysin5a | [Molecular Formula]
C66H96N11O13S+ | [MDL Number]
MFCD32201123 | [MOL File]
2055896-86-9.mol | [Molecular Weight]
1283.62 |
| Hazard Information | Back Directory | [Uses]
MC-VC(S)-PABQ-Tubulysin M is a synthetic ADC drug-linker conjugate composed of the tubulin polymerization inhibitor Tubulysin M (an ADC Cytotoxin) (HY-N7053) and MC-VC(S)- PABQ (an ADC linker) is connected. MC-VC(S)-PABQ-Tubulysin M is effective against multidrug-resistant lymphoma cell lines and tumors[1]. | [IC 50]
Auristatin | [References]
[1] Leanna R Staben, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041. DOI:10.1021/acsmedchemlett.7b00243 |
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