| Identification | Back Directory | [Name]
BLM-IN-1 | [CAS]
2056014-40-3 | [Synonyms]
BLM-IN-1
BLMIN1,BLM IN 1
Pyrrolo[2,1-b]quinazolin-9(1H)-one, 6-[[3-(diethylamino)propyl]amino]-7-fluoro-2,3-dihydro-3-[[4-(1-methylethyl)phenyl]methylene]-, (3E)- | [Molecular Formula]
C28H35FN4O | [MDL Number]
MFCD32062677 | [MOL File]
2056014-40-3.mol | [Molecular Weight]
462.6 |
| Chemical Properties | Back Directory | [Boiling point ]
630.0±65.0 °C(Predicted) | [density ]
1.16±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 8.33 mg/mL (18.01 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.33±0.25(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a KD valueof 1.81 μM. BLM-IN-1 has good inhibitory effect for BLM with an IC50 value of 0.95 μM. BLM-IN-1 can induce cell apoptosis. BLM-IN-1can be used for the research of DNA damage and cancer[1]. | [storage]
Store at -20°C | [References]
[1] Yin QK, et al. Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J Med Chem. 2019 Mar 28;62(6):3147-3162. DOI:10.1021/acs.jmedchem.9b00083 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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