| Identification | Back Directory | [Name]
3-Pyridinemethanamine,6-fluoro-(9CI) | [CAS]
205744-17-8 | [Synonyms]
(6-Fluoropyridin-3-yl)
6-Fluoro-3-pyridineMethanaMine
2-fluoro-5-(aminomethyl)pyridine
3-(Aminomethyl)-6-fluoropyridine
3-Pyridinemethanamine, 6-fluoro-
5-(Aminomethyl)-2-fluoropyridine
3-Pyridinemethanamine,6-fluoro-(9CI) | [Molecular Formula]
C6H7FN2 | [MDL Number]
MFCD11100747 | [MOL File]
205744-17-8.mol | [Molecular Weight]
126.13 |
| Chemical Properties | Back Directory | [Boiling point ]
63-65 °C(Press: 0.56 Torr) | [density ]
1.180±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
7.73±0.29(Predicted) | [Appearance]
Colorless to light yellow Liquid | [InChI]
InChI=1S/C6H7FN2/c7-6-2-1-5(3-8)4-9-6/h1-2,4H,3,8H2 | [InChIKey]
KYRWSLUCAPNJPI-UHFFFAOYSA-N | [SMILES]
C1=NC(F)=CC=C1CN |
| Hazard Information | Back Directory | [Uses]
6-Fluoro-3-pyridinemethanamine is a useful compound for the study of herbicidal activity of 2-cyano-3-[[(6-fluoro-3-pyridinyl)methyl]amino]acrylates. | [Synthesis]
General procedure for the synthesis of (6-fluoropyridin-3-yl)methanamine from 6-fluoro-3-cyanopyridine: 6-fluoro-3-cyanopyridine (300 mg, 2.46 mmol) was dissolved in 2 mol/L ammonia/methanol solution (30 mL), nickel Ruanne (0.5 g) was added at room temperature and the reaction was carried out for 12 h under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and washed with methanol (5 mL x 2). The filtrate was concentrated to dryness and the residue was purified by silica gel column chromatography (eluent ratio of dichloromethane: methanol = 100:4) to give 262 mg of yellow oily solid in 85% yield. | [References]
[1] Patent: CN106916101, 2017, A. Location in patent: Paragraph 0149; 0150
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 19, p. 7965 - 7983 |
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