| Identification | Back Directory | [Name]
1,2-Benzenedisulfonamide, N1-[(2R)-3-amino-2-hydroxypropyl]-4-(6-amino-3-pyridinyl)-3-(2H-tetrazol-5-yl)- | [CAS]
2058151-78-1 | [Synonyms]
MK-3402
1,2-Benzenedisulfonamide, N1-[(2R)-3-amino-2-hydroxypropyl]-4-(6-amino-3-pyridinyl)-3-(2H-tetrazol-5-yl)- | [Molecular Formula]
C15H19N9O5S2 | [MOL File]
2058151-78-1.mol | [Molecular Weight]
469.5 |
| Chemical Properties | Back Directory | [Boiling point ]
919.2±75.0 °C(Predicted) | [density ]
1.632±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.05±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MK-3402 (Compound303) is a metallo-beta-lactamase inhibitor, with IC50 values of 0.53, 0.25 and 0.169 nM against IMP-1, NDM-1, and VIM-1, respectively. MK-3402 can be used in bacterial research and shows a synergistic effect when used in combination with beta-lactam antibiotics[1]. | [IC 50]
IMP-1: 0.53 nM (IC50); NDM-1: 0.25 nM (IC50); VIM-1: 0.169 nM (IC50) | [References]
[1] Frank Bennett, et al. 3-tetrazolyl-benzene-1,2-disulfonamide derivatives as metallo-beta-lactamase inhibitors. Patent. WO2016210215. |
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