| Identification | Back Directory | [Name]
N-delta-chloroacetyl-L-ornithine | [CAS]
20584-81-0 | [Synonyms]
N-delta-chloroacetyl-L-ornithine
L-Ornithine, N5-(2-chloroacetyl)- | [Molecular Formula]
C7H13ClN2O3 | [MOL File]
20584-81-0.mol | [Molecular Weight]
208.64 |
| Chemical Properties | Back Directory | [Boiling point ]
469.0±45.0 °C(Predicted) | [density ]
1.303±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.49±0.24(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
N-ω-chloroacetyl-L-ornithine (NCAO) is a potent reversible competitive ornithine decarboxylase (ODC) inhibitor that exerts cytotoxic and antiproliferative effects on tumor cell lines with EC50 values ranging from 1 to 50.6 μM. NCAO induces tumor cell Apoptosis and inhibits tumor cell migration in vitro. NCAO also exhibits a potent antitumor activity against both solid and ascitic tumors in a mouse model using the myeloma (Ag8) cell line. NCAO is promising for research of antitumor agents[1]. | [References]
[1] Vargas-Ramírez AL, et al. N-ω-chloroacetyl-L-ornithine has in-vitro activity against cancer cell lines and in-vivo activity against ascitic and solid tumors. Anticancer Drugs. 2016 Jul;27(6):508-18. DOI:10.1097/CAD.0000000000000353 |
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