| Identification | Back Directory | [Name]
Darifenacin 3-Hydroxy Impurity | [CAS]
206048-82-0 | [Synonyms]
Darifenacin 3-Hydroxy Impurity
3-Pyrrolidineacetamide, 1-[2-(2,3-dihydro-3-hydroxy-5-benzofuranyl)ethyl]-α,α-diphenyl-, (3S)- | [Molecular Formula]
C28H30N2O3 | [MOL File]
206048-82-0.mol | [Molecular Weight]
442.56 |
| Chemical Properties | Back Directory | [Boiling point ]
644.1±55.0 °C(Predicted) | [density ]
1.247±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble; Methanol: soluble | [form ]
A solid | [pka]
13.52±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
3-hydroxy Darifenacin is a metabolite of darifenacin . It is an antagonist of M1-5 muscarinic receptors (Kis = 17.78, 79.43, 2.24, 36.31, and 6.17 nM, respectively, in CHO cells). | [Uses]
3-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033). 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells[1]. | [storage]
Store at -20°C | [References]
[1] Mansfield KJ, et al. Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa. J Pharmacol Exp Ther. 2009 Mar;328(3):893-9. DOI:10.1124/jpet.108.145508 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Pharma Affiliates
|
| Tel: |
172-5066494 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList694812/0.htm |
|