| Identification | Back Directory | [Name]
t-Boc-Aminooxy-PEG4-CH2CO2-t-Bu | [CAS]
2062663-63-0 | [Synonyms]
Boc-Aminooxy-PEG4-CH2-Boc
t-Boc-Aminooxy-PEG4-CH2CO2-t-Bu
3,6,9,12,15-Pentaoxa-2-azaheptadecanedioic acid, 1,17-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C19H37NO9 | [MDL Number]
MFCD30536164 | [MOL File]
2062663-63-0.mol | [Molecular Weight]
423.5 |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG4-CH2CO2-t-Bu is a PEG linker with a t-Boc protected aminooxy group and a t-Bu carboxylic acid group. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a stable oxime linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound. | [Uses]
Boc-Aminooxy-PEG4-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651 |
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