| Identification | Back Directory | [Name]
[1,1′-Biphenyl]-4-acetamide, α-[(3,3-dimethyl-1-oxobutyl)amino]-3′,4′,5′-trifluoro-N-hydroxy- | [CAS]
2065197-82-0 | [Synonyms]
[1,1′-Biphenyl]-4-acetamide, α-[(3,3-dimethyl-1-oxobutyl)amino]-3′,4′,5′-trifluoro-N-hydroxy- | [Molecular Formula]
C20H21F3N2O3 | [MOL File]
2065197-82-0.mol | [Molecular Weight]
394.39 |
| Hazard Information | Back Directory | [Uses]
MMV1557817 is an orally active and potent antimalarial compound. MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to inhibition of end-stage hemoglobin digestion in asexual parasites[1]. | [IC 50]
Plasmodium | [References]
[1] Edgar RCS, et al. On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio. 2024 Jun 12;15(6):e0096624. DOI:10.1128/mbio.00966-24 |
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