| Identification | Back Directory | [Name]
(S)-C33 | [CAS]
2066488-39-7 | [Synonyms]
(S)-C33
PDE9IN(S)C33
PDE9-IN-(S)-C33
PDE9 IN (S) C33
PDE9A inhibitor C33(S) - (S)-C33
6-[[(1S)-1-(4-Chlorophenyl)ethyl]amino]-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
4H-Pyrazolo[3,4-d]pyrimidin-4-one, 6-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-1-cyclopentyl-1,5-dihydro- | [Molecular Formula]
C18H20ClN5O | [MDL Number]
MFCD31579858 | [MOL File]
2066488-39-7.mol | [Molecular Weight]
357.84 |
| Chemical Properties | Back Directory | [Boiling point ]
556.6±60.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
1.08±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research[1]. | [IC 50]
PDE9A: 11 ± 4 nM (IC50); PDE5A1: 366 ± 38 nM (IC50); PDE1B: 554 ± 64 nM (IC50); PDE4D2: 1.3 ± 0.1 μM (IC50); PDE10A1: 2.3 ± 0.3 μM (IC50); PDE2A: 2.4 ± 0.5 μM (IC50) | [References]
[1] Huang M, Shao Y, Hou J, et al. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol Pharmacol. 2015;88(5):836-845. DOI:10.1124/mol.115.099747 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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