| Hazard Information | Back Directory | [Description]
JBJ-03-142-02 is a highly potent EGFR and ErbB2 inhibitor that inhibits wild type and mutated receptors. | [Uses]
EGFR-IN-99 (compound 1a) is a potent EGFR and HER2 Exon 20 insertion mutant inhibitor. EGFR-IN-99 has excellent antiproliferative activity against DFCI127 cells, with an EC50 of 11.5 nM. EGFR-IN-99 can be used for the research of non-small cell lung cancer (NSCLC)[1]. | [storage]
Store at -20°C | [References]
[1] Jang J,et al. Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11629-11633. DOI:10.1002/anie.201805187 |
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