| Identification | Back Directory | [Name]
Chlorhexidine diacetate | [CAS]
206986-79-0 | [Synonyms]
Chlorhexidine diacetate
CHLORHEXIDINE DIACETATE HYDRATE, 98
2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, acetate, hydrate (1:2:)
2-[N'-[6-[[Amino-[[amino-[(4-chlorophenyl)amino]methylidene]amino]methylidene]amino]hexyl]carbamimidoyl]-1-(4-chlorophenyl)guanidine diacetate | [EINECS(EC#)]
205-516-1 | [Molecular Formula]
C22 H30 Cl2 N10 . 2 C2 H4 O2 . x H2 O | [MDL Number]
MFCD00150042 | [MOL File]
206986-79-0.mol | [Molecular Weight]
625.55 |
| Chemical Properties | Back Directory | [Appearance]
white to almost white powder | [Melting point ]
153-157°C | [storage temp. ]
room temp | [solubility ]
DMF: 15 mg/mL; DMSO: 15 mg/mL; DMSO:PBS(pH 7.2) (1:2): 0.33 mg/mL; Ethanol: 10 mg/mL | [form ]
Powder | [color ]
White to almost white | [InChIKey]
STXIUCWIIZWUGG-UHFFFAOYSA-N | [SMILES]
N(C1C=CC(Cl)=CC=1)C(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1C=CC(Cl)=CC=1.C(=O)(O)C |
| Hazard Information | Back Directory | [Chemical Properties]
white to almost white powder | [Uses]
Antipsychotic | [Definition]
ChEBI: Chlorhexidine acetate is the acetate salt of chlorhexidine. It is a disinfectant used for bacterial control in hospital, agricultural and domestic environments. It has a role as an antibacterial agent, an antiinfective agent, an antifungal agent and an antifouling biocide. It contains a chlorhexidine. | [Biochem/physiol Actions]
Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective against both Gram-positive and Gram-negative bacteria. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. | [in vivo]
| Animal Model: | One hundred and eighty male Imprinting Control Region (ICR) mice at 6 to8-wk-old (body weight, 25 ± 3 g) were randomized to six groups[1]. | | Dosage: | Chlorhexidine gluconate 0.05%, and Chlorhexidine gluconate 0.025%. | | Administration: | One-time intraperitoneal injection. | | Result: | A total of 48 mice (26.7%) developed postoperative intra-abdominal abscesses. Mice that had Chlorhexidine gluconate 0.05% lavage had significantly lower incidence of postoperative intra-abdominal abscesses compared with that of group D mice that had saline lavage only (P = 0.0113). Microscopic peritoneal fibrosis occurred significantly more among group E mice that had Chlorhexidine gluconate 0.05% lavage compared with group D mice that had saline lavage only (P = < 0.005). |
|
|
|