| Hazard Information | Back Directory | [Uses]
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2]. | [in vivo]
SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2]. | Animal Model: | YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneally injection; every 2 d; for 22 days | | Result: | Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice. |
| [References]
[1] Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978. DOI:10.12659/MSM.927978
[2] Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499. DOI:10.7150/thno.60031 |
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