| Identification | Back Directory | [Name]
SJB3-019A | [CAS]
2070015-29-9 | [Synonyms]
SJB3-019A
SJB-3-019A,SJB3 019A,SJB3019A
2-(Pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione
Naphth[2,3-d]oxazole-4,9-dione, 2-(3-pyridinyl)- | [Molecular Formula]
C16H8N2O3 | [MDL Number]
MFCD26960956 | [MOL File]
2070015-29-9.mol | [Molecular Weight]
276.25 |
| Chemical Properties | Back Directory | [Boiling point ]
526.1±52.0 °C(Predicted) | [density ]
1.426±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
2.74±0.12(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM. | [Biological Activity]
potent USP1 inhibitor th at induces ID1 degradationupregulation of p21 and cytoxicity in K562 and other leukemic cell lines | [References]
[1] Helena Mistry, et al. Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther Published OnlineFirst October 15, 2013. DOI:10.1158/1535-7163.MCT-13-0103-T |
|
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
|