| Identification | Back Directory | [Name]
DIHYDROFISETIN | [CAS]
20725-03-5 | [Synonyms]
FUSTIN
FUSTIN 97%
FUSTIN(SH)
DIHYDROFISETIN
2,3-DIHYDROFISETH
2,3-DIHYDROFISETIN
5-Deoxydihydrouercetin
3',4',7-TRIHYDROXYFLAVANONOL
3,7,3',4'-TETRAHYDROXYFLAVANONE
3,3',4',7-TETRAHYDROXYFLAVANONE
3,3,4,7-TETRAHYDROXYFLAVANONE 97%
3,7,3'',4''-TETRAHYDROXYFLAVANONE WITH HPLC
rel-(2α*)-3β*,3',4',7-Tetrahydroxyflavanone
trans-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-4-benzopyrone
rel-(2R*)-2α*-(3,4-Dihydroxyphenyl)-3β*,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-, (2R,3R)-rel- | [EINECS(EC#)]
243-989-6 | [Molecular Formula]
C15H12O6 | [MDL Number]
MFCD00075647 | [MOL File]
20725-03-5.mol | [Molecular Weight]
288.25 |
| Chemical Properties | Back Directory | [Melting point ]
216-217°C | [Boiling point ]
644.2±55.0 °C(Predicted) | [density ]
1.599±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Acetone: soluble,Chloroform: soluble,Dichloromethane: soluble,DMSO: soluble,Ethyl Acetate: soluble | [form ]
A solid | [pka]
7.59±0.60(Predicted) | [color ]
White to off-white | [LogP]
0.870 |
| Hazard Information | Back Directory | [Uses]
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1]. | [Definition]
ChEBI: A dihydroflavonol that is the 2,3-dihydro derivative of fisetin. | [in vivo]
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) attenuates Aβ (1-42)-induced impairments in conditioned fear learning and passive avoidance behavior[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice[1]. | Animal Model: | Aβ-treated C57BL/6 mice[1] | | Dosage: | 50 and 100 mg/kg | | Administration: | Oral administration;daily, for 11days | | Result: | Decreased freezing response in Aβ-treated C57BL/6 mice. |
| Animal Model: | Aβ-treated C57BL/6 mice[1] | | Dosage: | 50 and 100 mg/kg | | Administration: | Oral administration;daily, for 11days | | Result: | Increased the expression of Ach, ChAT gene and ChAT activity. Decreased the expression of AChE gene and AChE activity. |
| Animal Model: | Aβ-treated C57BL/6 mice[1] | | Dosage: | 50 and 100 mg/kg | | Administration: | Oral administration;daily, for 11days | | Result: | Increased gene expression of M2- , M3- ,M4-, M5-, α4β, α7-receptor, p-ERK and p-CREB. |
| [storage]
-20°C | [References]
[1] Jin CH, et, al. Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment. J Neurosci Res. 2009 Dec;87(16):3658-70. DOI:10.1002/jnr.22159 |
|
| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm |
| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
|