| Identification | Back Directory | [Name]
2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]- | [CAS]
2075787-77-6 | [Synonyms]
MC2664
HDAC-IN-52
2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]- | [Molecular Formula]
C24H20N4O2 | [MOL File]
2075787-77-6.mol | [Molecular Weight]
396.44 |
| Chemical Properties | Back Directory | [Boiling point ]
632.7±55.0 °C(Predicted) | [density ]
1.359±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.12±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
HDAC-IN-52 is a pyridine-containing HDAC inhibitor, with IC50s of 0.189, 0.227, 0.440 and 0.446 μM for HDAC1, HDAC2, HDAC3, and HDAC10, respectively. HDAC-IN-52 can be used for the research of cancer[1]. | [IC 50]
hHDAC1: 0.189 μM (IC50); hHDAC2: 0.227 μM (IC50); hHDAC3: 0.440 μM (IC50); hHDAC10: 0.446 μM (IC50) | [References]
[1] Bello ED, et, al. Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells. Eur J Med Chem. 2022 Dec 15;247:115022. DOI:10.1016/j.ejmech.2022.115022 |
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