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GLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) with an IC50 value of 1.14 nM. GLL398 shows a strong dose-dependent binding to ER with a mutation at Y537S (IC50=29.5 nM). GLL398 blocks tumor growth in xenograft models of breast cancer. | [References]
[1] Guo S, et al. GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models. Breast Cancer Res Treat. 2020;180(2):359-368. DOI:10.1007/s10549-020-05558-w |
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| Company Name: |
Cckinase, Inc.
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| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
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