| Identification | Back Directory | [Name]
2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo- | [CAS]
207920-87-4 | [Synonyms]
L-I-OddU
2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo- | [Molecular Formula]
C8H9IN2O5 | [MOL File]
207920-87-4.mol | [Molecular Weight]
340.07 |
| Hazard Information | Back Directory | [Uses]
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis[1][2]. | [References]
[1] Kira T, et, al. Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase. Antimicrob Agents Chemother. 2000 Dec;44(12):3278-84. DOI:10.1128/AAC.44.12.3278-3284.2000
[2] Focher F, et, al. Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development. Curr Drug Targets Infect Disord. 2003 Mar;3(1):41-53. DOI:10.2174/1568005033342163 |
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