| Identification | Back Directory | [Name]
PS-432 | [CAS]
2083630-26-4 | [Synonyms]
PS-432
PS432 >=98% (HPLC)
1H-Pyrrole-3-carboxylic acid, 2-[5-(4-chlorophenyl)-2-furanyl]-2,5-dihydro-4-hydroxy-1-(6-methyl-2-benzothiazolyl)-5-oxo-, ethyl ester | [Molecular Formula]
C25H19ClN2O5S | [MDL Number]
MFCD31579823 | [MOL File]
2083630-26-4.mol | [Molecular Weight]
494.95 |
| Chemical Properties | Back Directory | [Boiling point ]
662.5±65.0 °C(Predicted) | [density ]
1.463±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
4.50±1.00(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C25H19ClN2O5S/c1-3-32-24(31)20-21(18-11-10-17(33-18)14-5-7-15(26)8-6-14)28(23(30)22(20)29)25-27-16-9-4-13(2)12-19(16)34-25/h4-12,21,29H,3H2,1-2H3 | [InChIKey]
NBZPOMWJBSLLCT-UHFFFAOYSA-N | [SMILES]
N1(C2=NC3=CC=C(C)C=C3S2)C(=O)C(O)=C(C(OCC)=O)C1C1=CC=C(C2=CC=C(Cl)C=C2)O1 |
| Hazard Information | Back Directory | [Description]
PS432 is an allosteric inhibitor of atypical PKCs. It has been shown to target the PIF-pocket and significantly reduce tumor growth without side effects in mouse xenograft model. | [Uses]
PS432 is a PKC inhibitor with IC50s of 16.9 μM (PKCι) and 18.5 μM (PKCζ), respectively. PS432 effectively inhibits the proliferation of non-small cell lung cancer cells (NSCLCs) and tumor growth in mouse xenograft models[1]. | [in vivo]
PS432 (2.5 mg/kg; i.p.; once daily for 14 d) inhibits tumor growth in xenograft model of lung cancer[1]. | [IC 50]
PKCζ: 18.5 μM (IC50); PKCι: 16.9 μM (IC50) | [References]
[1] Arencibia JM, et al. An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. ACS Chem Biol. 2017 Feb 17;12(2):564-573. DOI:10.1021/acschembio.6b00827 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|