| Identification | Back Directory | [Name]
MMP-3 INHIBITOR VIII | [CAS]
208663-26-7 | [Synonyms]
MMP3 inhibitor 2
MMP-3 INHIBITOR VIII
2-[benzyl-(4-methoxyphenyl)sulfonylamino]-N-hydroxy-4-methylpentanamide
N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL]-[BENZYLAMINO]-4-METHYLPENTANAMIDE
Pentanamide, N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](phenylmethyl)amino]-4-methyl- | [Molecular Formula]
C20H26N2O5S | [MDL Number]
MFCD00932464 | [MOL File]
208663-26-7.mol | [Molecular Weight]
406.5 |
| Chemical Properties | Back Directory | [density ]
1.245±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
9.13±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity. This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM. | [Uses]
MMP12-IN-3 (compound 32) is a potent MMP12 inhibitor with an IC50 value of 4.9 nM. MMP12-IN-3 has the potential for the research of chronic respiratory diseases such as emphysema[1]. | [IC 50]
MMP-12: 4.9 nM (IC50) | [References]
[1] Jeng AY, et al. Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase. Bioorg Med Chem Lett. 1998 Apr 21;8(8):897-902. DOI:10.1016/s0960-894x(98)00142-5 |
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