| Identification | Back Directory | [Name]
Acid-PEG1-t-butyl ester | [CAS]
2086689-08-7 | [Synonyms]
COOH-PEG1-OtBu
COOH-PEG1-COOtBu
Acid-PEG1-C2-Boc
Acid-PEG1-t-butyl ester
3-(3-(tert-Butoxy)-3-oxopropoxy)propanoic acid
3-(2-Carboxyethoxy)propanoic acid 1-tert-butyl ester
Propanoic acid, 3-(2-carboxyethoxy)-, 1-(1,1-dimethylethyl) ester | [Molecular Formula]
C10H18O5 | [MDL Number]
MFCD30723273 | [MOL File]
2086689-08-7.mol | [Molecular Weight]
218.25 |
| Chemical Properties | Back Directory | [Boiling point ]
341.9±22.0 °C(Predicted) | [density ]
1.101±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
4.27±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Acid-PEG1-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Acid-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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