| Identification | Back Directory | [Name]
Carbamic acid, N-[3-[[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl]amino]propyl]-, 4-cycloocten-1-yl ester | [CAS]
2087490-43-3 | [Synonyms]
Carbamic acid, N-[3-[[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl]amino]propyl]-, 4-cycloocten-1-yl ester | [Molecular Formula]
C31H37ClN6O3S | [MOL File]
2087490-43-3.mol | [Molecular Weight]
609.18 |
| Hazard Information | Back Directory | [Uses]
JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2]. | [IC 50]
BRD4 | [References]
[1] Hu Z, et al. Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic. Chembiochem. 2022 Jan 19;23(2):e202100270. DOI:10.1002/cbic.202100270
[2] Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401. DOI:10.1126/science.aal2066 |
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