| Identification | Back Directory | [Name]
(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-N-methylpropanamide | [CAS]
2088032-52-2 | [Synonyms]
Levothyroxine Impurity 49
N-Methylamide Levothyroxine
Levothyroxine USP Impurity b
Levothyroxine N-Methylamide (USP)
(S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-N-methylpropanamide
(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-N-methylpropanamide | [Molecular Formula]
C16H14I4N2O3 | [MDL Number]
MFCD28358811 | [MOL File]
2088032-52-2.mol | [Molecular Weight]
789.912 |
| Chemical Properties | Back Directory | [Boiling point ]
623.2±55.0 °C(Predicted) | [density ]
2.448±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: Slightly soluble,PBS (pH 7.2): 0.20 mg/ml | [form ]
A solid | [pka]
6.90±0.25(Predicted) |
| Hazard Information | Back Directory | [Uses]
(S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-N-methylpropanamide is an impurity of levothyroxine. Levothyroxine is an impurity of Thyroxine (T425600), one of the thyroid hormones involved in the maintenance of metabolic homeostasis, synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. |
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