| Chemical Properties | Back Directory | [density ]
1.452±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 5mg/mL, clear (warmed) | [form ]
powder | [pka]
11.23±0.46(Predicted) | [color ]
white to beige | [InChIKey]
ZBSPMOBILDLOCV-UHFFFAOYSA-N | [SMILES]
F[S](=O)(=O)c1ccc(cc1)CN2CCN(CC2)c3nc(cc(n3)C(=O)NCC#C)Nc4n[nH]c(c4)C5CC5 |
| Hazard Information | Back Directory | [Uses]
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in CDK2 and CDK1. XO44 also labels CDK4 proteins in cells[1][2]. | [Biochem/physiol Actions]
PF-6808472 is a cell permeable covalent probe suitable for click chemistry designated to measure kinase selectivity in intact cells. PF-6808472 contains sulfonyl fluoride group, which react with conserved lysine residue within kinase ATP binding site. | [IC 50]
CDK4; CDK1; CDK2 | [References]
[1] Kevin D Freeman-Cook, et al. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J Med Chem. 2021 Jul 8;64(13):9056-9077. DOI:10.1021/acs.jmedchem.1c00159
[2] Guiley KZ, et al. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 Dec 13;366(6471):eaaw2106. DOI:10.1126/science.aaw2106 |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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Merck KGaA
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www.sigmaaldrich.cn |
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