| Hazard Information | Back Directory | [Description]
MTC420 is a anti-tuberculosis agent. MTC420 displays acceptable anti-tuberculosis activity (Mtb IC50 =525 nM, Mtb Wayne IC50 = 76 nM and MDR Mtb patient isolates IC50 = 140 nM) and favourable pharmacokinetic and toxicological profiles. | [Uses]
MTC420 (compound 42a) is a heterocyclic quinolone compound that targets the respiratory chain of Mycobacterium tuberculosis and exhibits antituberculosis activity (Rep Mtb: IC50=525 nM, Wayne Mtb: IC50=76 nM, MDR Mtb: IC50=140 nM)[1]. | [IC 50]
Rep Mtb: 525 nM (IC50); Wayne Mtb: 76 nM (IC50); MDR Mtb: 140 nM (IC50) | [References]
[1] Hong W D, et al. Rational design, synthesis, and biological evaluation of heterocyclic quinolones targeting the respiratory chain of Mycobacterium tuberculosis[J]. Journal of Medicinal Chemistry, 2017, 60(9): 3703-3726. DOI:10.1021/acs.jmedchem.6b01718 |
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