| Identification | Back Directory | [Name]
AOH1160 | [CAS]
2089314-57-6 | [Synonyms]
AOH1160
1-Naphthalenecarboxamide, N-[2-oxo-2-[(2-phenoxyphenyl)amino]ethyl]- | [Molecular Formula]
C25H20N2O3 | [MDL Number]
MFCD01275905 | [MOL File]
2089314-57-6.mol | [Molecular Weight]
396.44 |
| Chemical Properties | Back Directory | [Boiling point ]
681.5±40.0 °C(Predicted) | [density ]
1.270±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
12.77±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis[1]. | [in vivo]
AOH1160 (40 mg/kg, gavage once a day) can inhibit the growth of breast cancer and small cell lung cancer in mice[1].
| [References]
[1] Gu L, et al. The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res. 2018 Dec 1;24(23):6053-6065. DOI:10.1158/1078-0432.CCR-18-0592 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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