| Identification | Back Directory | [Name]
4-FPBUA | [CAS]
2089636-93-9 | [Synonyms]
4-FPBUA
1(9bH)-Dibenzofuranone, 2-acetyl-6-[(2E)-3-(4′-fluoro[1,1′-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-3,7,9-trihydroxy-8,9b-dimethyl-, (9bS)- | [Molecular Formula]
C31H23FO7 | [MOL File]
2089636-93-9.mol | [Molecular Weight]
526.51 |
| Chemical Properties | Back Directory | [Boiling point ]
774.173±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.491±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
4.500±1.00(predicted) |
| Hazard Information | Back Directory | [Uses]
4-FPBUA is a semisynthetic analog of usnic acid (HY-W015883) that can enhance cellular blood-brain barrier (BBB) function and increase the transport of Amyloid β (Aβ) across monolayer cells. 4-FPBUA is also an inhibitor of mTOR, capable of enhancing cellular Autophagy, thereby reversing BBB disruption in vivo and being utilized in research for Alzheimer's disease[1]. | [References]
[1] Al Rihani S B, et al. The Usnic Acid Analogue 4-FPBUA Enhances the Blood–Brain Barrier Function and Induces Autophagy in Alzheimer’s Disease Mouse Models[J]. ACS Chemical Neuroscience, 2024. DOI:10.1021/acschemneuro.4c00326 |
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