| Chemical Properties | Back Directory | [Boiling point ]
323.7±42.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,protect from light | [form ]
Solid | [pka]
11?+-.0.70(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water : 36.67 mg/mL (220.70 mM) |
| Hazard Information | Back Directory | [Uses]
SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity[1]. | [in vivo]
SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model[1]. | [References]
[1] Stephen C. Alley, et al. Abstract DDT02-02: SGN-2FF: A novel small molecule inhibitor of fucosylation with preclinical antitumor activity through multiple immune mechanisms. Cancer Res 2017;77(13 Suppl). |
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