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Tilsotolimod (sodium) is a synthetic Toll-like receptor 9 (TLR9) agonist that has demonstrated antitumor activity in preclinical models. | [References]
[1] Karime C, Wang J, Woodhead G, et al. Tilsotolimod: an investigational synthetic toll-like receptor 9 (TLR9) agonist for the treatment of refractory solid tumors and melanoma.?Expert Opin Investig Drugs. 2022;31(1):1-13. DOI:10.1080/13543784.2022.2019706
[2] Haymaker C, Johnson DH, Murthy R, et al. Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti-PD-1 Refractory Melanoma.?Cancer Discov. 2021;11(8):1996-2013. DOI:10.1158/2159-8290.CD-20-1546 |
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