| Identification | Back Directory | [Name]
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester | [CAS]
2093152-78-2 | [Synonyms]
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester | [Molecular Formula]
C25H45NO9 | [MDL Number]
MFCD30723293 | [MOL File]
2093152-78-2.mol | [Molecular Weight]
503.63 |
| Chemical Properties | Back Directory | [Boiling point ]
546.2±50.0 °C(Predicted) | [density ]
1.069±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DMF, DCM | [pka]
-1.61±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a click chemistry branched linker. The propargyl group can react with azide-bearing compounds through Click Chemistry, the t-butyl protected carboxyl group can also be deprotected under mild acidic conditions. | [Uses]
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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