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2093152-86-2

2093152-86-2 Structure

2093152-86-2 Structure
IdentificationBack Directory
[Name]

N-(Amino-PEG5)-N-bis(PEG4-acid)
[CAS]

2093152-86-2
[Synonyms]

LUN 52862
N-(Amino-PEG5)-N-bis(PEG4-acid)
[Molecular Formula]

C34H68N2O17
[MDL Number]

MFCD30723284
[MOL File]

2093152-86-2.mol
[Molecular Weight]

776.91
Chemical PropertiesBack Directory
[Boiling point ]

801.4±65.0 °C(Predicted)
[density ]

1.154±0.06 g/cm3(Predicted)
[solubility ]

Soluble in Water, DMSO, DMF
[form ]

Viscous Liquid
[pka]

3.97±0.10(Predicted)
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Description]

N-(Amino-PEG5)-N-bis(PEG4-acid) is a aqueous soluble PEG linker with an amino group with two terminal carboxylic acids. The amino group is reactive with carboxylic acids, activated NHS esters. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
[Uses]

N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids[1].
[IC 50]

PEGs
[References]

[1] Pignatello, R., et al. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG5000 polymers. Materials Science and Engineering: C, 2015.46, 470– DOI:10.1016/j.msec.2014.10.054
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