| Chemical Properties | Back Directory | [Boiling point ]
867.7±65.0 °C(predicted) | [density ]
1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
11.96±0.20(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC). PBD-monoamide has DNA-binding activity and reduces cell viability[1]. | [References]
[1] Lewis GD, et al. The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results. Nat Commun. 2024 Jan 11;15(1):466. DOI:10.1038/s41467-023-44533-z |
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