| Identification | Back Directory | [Name]
CYP17-IN-1 | [CAS]
2093317-51-0 | [Synonyms]
CYP17-IN-1
CYP17IN1,CYP17 IN 1,CYP-17-IN-1
[1]Benzothieno[2,3-c]pyridine, 6-fluoro-1,2,3,4-tetrahydro-2-[(4-methyl-3-pyridinyl)methyl]- | [Molecular Formula]
C18H17FN2S | [MDL Number]
MFCD32174250 | [MOL File]
2093317-51-0.mol | [Molecular Weight]
312.4 |
| Chemical Properties | Back Directory | [Boiling point ]
471.3±40.0 °C(Predicted) | [density ]
1.285±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
5.88±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1]. | [in vivo]
CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1]. | [IC 50]
CYP17 | [References]
[1] Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172. DOI:10.1016/j.ejmech.2017.03.037 |
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