2093386-39-9

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2093386-39-9 Structure

Identification	Back Directory
[Name] 4-[(5-Aminopentyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
[CAS] 2093386-39-9
[Synonyms] Thalidomide-4-NH-C5-NH2 4-[(5-Aminopentyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl 1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)amino]-2-(2,6-dioxo-3-piperidinyl)- 4-[(5-aminopentyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
[Molecular Formula] C18H22N4O4
[MOL File] 2093386-39-9.mol
[Molecular Weight] 358.39

Hazard Information	Back Directory
[Uses] Thalidomide-NH-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
[IC 50] Cereblon
[References] [1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326 [2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

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