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2093388-20-4

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2093388-20-4 Structure

2093388-20-4 Structure
IdentificationBack Directory
[Name]

4-((3-aminopropyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
[CAS]

2093388-20-4
[Synonyms]

Thalidomide-NH-C3-NH2 HCl
4-((3-aminopropyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
[Molecular Formula]

C16H18N4O4
[MOL File]

2093388-20-4.mol
[Molecular Weight]

330.34
Chemical PropertiesBack Directory
[Boiling point ]

635.2±55.0 °C(Predicted)
[density ]

1.449±0.06 g/cm3(Predicted)
[pka]

10.75±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Pomalidomide-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].
[IC 50]

Cereblon
[References]

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
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