| Identification | Back Directory | [Name]
LADOSTIGIL | [CAS]
209394-27-4 | [Synonyms]
LADOSTIGIL
Ladostigil (TV-3,326)
LHXOCOHMBFOVJS-OAHLLOKOSA-N
Carbamic acid, N-ethyl-N-methyl-, (3R)-2,3-dihydro-3-(2-propyn-1-ylamino)-1H-inden-5-yl ester | [Molecular Formula]
C16H20N2O2 | [MDL Number]
MFCD09752948 | [MOL File]
209394-27-4.mol | [Molecular Weight]
272.34 |
| Hazard Information | Back Directory | [Uses]
Treatment of Alzheimer’s disease (an inhibitor of
monoamine oxidase (MAO-A and B), an acetylcholinesterase inhibitor, and a neuroprotectant). | [Definition]
ChEBI: Ladostigil is a member of indanes. | [in vivo]
Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats[4].
Ladostigil (50 μmol/kg; single p.o.) restores the loss of episodic memory in the object recognition test in rats[3]. | Animal Model: | Pathogen-free (SPF) Sprague-Dawley rats[4] | | Dosage: | 17 mg/kg | | Administration: | P.o. (added to the drinking water) daily for 6 weeks | | Result: | Inhibited brain MAO-A and B by more than 60%.
Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.
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| [IC 50]
MAO-B: 37.1 μM (IC50); AChE: 31.8 μM (IC50) |
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| Company Name: |
LGM Pharma
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| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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