| Identification | Back Directory | [Name]
SB271046 | [CAS]
209481-20-9 | [Synonyms]
CS-1869
SB 271046
SB 737050
SB271046 HCL
SB271046 USP/EP/BP
SB 271046 (SB-271046A)
SB 271046 hydrochloride
SB271046 5-HT6 receptor antagonist orally active SB-271046
Benzo[b]thiophene-2-sulfonamide, 5-chloro-N-[4-methoxy-3-(1-pipe
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide
5-Chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide
Benzo[b]thiophene-2-sulfonaMide, 5-chloro-N-[4-Methoxy-3-(1-piperazinyl)phenyl]-3-Methyl-
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide SB 271046
5-Chloro-3-Methyl-Benzo[b]Thiophene-2-Carboxylic Acid (4-Methoxy-3-Piperazin-1-yl-Phenyl)-AMide H
1. 5-Chloro-3-Methyl-Benzo[b]Thiophene-2-Carboxylic Acid (4-Methoxy-3-Piperazin-1-yl-Phenyl)-AMide H
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-benzo[b]thiophen-2-sulfonamide hydrochloride
5-chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
SB 271046 hydrochloride/5-chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
SB271046 hydrochloride 5-Chloro-N-[4-Methoxy-3-(1-piperazinyl)phenyl]-3-Methylbenzo[b]thiophene-2-sulfonaMide | [Molecular Formula]
C20H22CIN3O3S2.HCl | [MDL Number]
MFCD05662312 | [MOL File]
209481-20-9.mol | [Molecular Weight]
488.451 |
| Chemical Properties | Back Directory | [Melting point ]
240-241℃ (DEC.) | [Boiling point ]
664.3±65.0 °C(Predicted) | [density ]
1.400 | [storage temp. ]
Desiccate at RT | [solubility ]
Soluble in DMSO > 10 mM | [form ]
Powder | [pka]
7.61±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
SB 271046 is a potent, selective and orally active 5-HT6 receptor antagonist with a pKi of 8.92-9.09. SB 271046 show >200-fold selective for the 5-HT6 receptor over other receptors, binding sites and ion channels. SB 271046 has anticonvulsant activity[1]. | [in vivo]
SB 271046 produces an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of ?0.1?mg/kg p.o. and maximum effect at 4?h post-dose. The level of anticonvulsant activity achieved correlated well with the blood concentrations of SB 271046 (EC50 of 0.16?μM) and brain concentrations of 0.01-0.04?μM at Cmax[1]. | [IC 50]
5-HT6 Receptor: 8.92-9.09 (pKi) | [storage]
room temperature (desiccate) | [References]
[1] C Routledge, et al. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. Br J Pharmacol. 2000 Aug;130(7):1606-12. DOI:10.1038/sj.bjp.0703457 |
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