| Identification | Back Directory | [Name]
2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- | [CAS]
2094893-05-5 | [Synonyms]
EN523
2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- | [Molecular Formula]
C12H14N2O3 | [MOL File]
2094893-05-5.mol | [Molecular Weight]
234.25 |
| Chemical Properties | Back Directory | [Boiling point ]
529.6±50.0 °C(Predicted) | [density ]
1.225±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 250 mg/mL (1067.24 mM; Need ultrasonic) | [form ]
Solid | [pka]
-0.21±0.20(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C12H14N2O3/c1-3-10(15)13-6-7-14(11(16)8-13)12-5-4-9(2)17-12/h3-5H,1,6-8H2,2H3 | [InChIKey]
KYXPDOMFYBFXKO-UHFFFAOYSA-N | [SMILES]
N1(C2=CC=C(C)O2)CCN(C(=O)C=C)CC1=O |
| Hazard Information | Back Directory | [Uses]
EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1[1]. | [Biological Activity]
EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1[1]. | [References]
[1]. Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022;18(4):412-421. |
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