2094993-48-1

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2094993-48-1 Structure

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[Name] Cyclotheonellazole A
[CAS] 2094993-48-1
[Synonyms] Cyclotheonellazole A

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[Uses] Cyclotheonellazole A is a natural macrocyclic peptide and a potent elastase inhibitor (IC50=0.034 nM). Cyclotheonellazole A inhibits chymotrypsin with an IC50 value of 0.62 nM[1][2].
[References] [1] Cui Y, et al. Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury. J Med Chem. 2022;65(4):2971-2987. DOI:10.1021/acs.jmedchem.1c01583

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